stent delivery device

专利摘要:
ENDOVASCULAR PROSTHESIS AND DISTRIBUTION DEVICE. In one of its aspects, the present invention relates to a stent. The stent comprises a first expandable portion expandable from a first unexpanded state to a second expanded state to bias the first expandable portion against a vascular lumen and a retractable sheet portion attached to the first expandable portion. The retractable sheet portion comprises at least a spine portion and a plurality of rib portions attached to the spine portion. Longitudinally adjacent pairs of rib portions are free from interconnecting struts. The stent that can be uncoated and re-coated for repositioning the stent prior to final stent implantation. Also described is a delivery device that is particularly well suited for delivering the present stent through tortuous vasculature in the body.
公开号:BR112013027216B1
申请号:R112013027216-3
申请日:2012-04-27
公开日:2021-05-25
发明作者:Jonathan G. Tippett；Eric Soun-Sang Fung；Cassie A. Borsky
申请人:Evysio Medical Devices Ulc；
IPC主号:

专利说明:

REFERENCE REFERENCE TO RELATED REQUEST
[001] The present application claims benefit under 35 USC §119(e) of Provisional Patent Application SN 61/457,504 and SN 61/457,604, each filed April 29, 2011, the contents of which are hereby incorporated herein by way of reference. Background of the invention: Field of invention:
[002] In one of its aspects, the present invention relates to an endovascular graft. In another of its aspects, the present invention relates to a method of treating an aneurysm in a patient. In another of its aspects, the present invention relates to a stent delivery device. Other aspects of the invention will be apparent to those skilled in the art having in mind the present specification. Description of prior art
[003] As known in the art, an aneurysm is an abnormal bulging outwardly in the wall of an artery. In some cases, the bulge may be in the form of a smooth bulge outward in all directions from the artery - this is known as a "fusiform aneurysm". In other cases, the bulge may be in the form of a sac originating from an artery branch point or one side of the artery - this is known as a "sacular aneurysm".
[004] Although aneurysms can occur in any artery in the body, it is usually those that occur in the brain that lead to the occurrence of a stroke. Most saccular aneurysms that occur in the brain have a neck that extends from the cerebral blood vessel and widens into a pocket that protrudes away from the vessel.
[005] The problems caused by such aneurysms can occur in several different ways. For example, if the aneurysm ruptures, blood enters the brain in the subarachnoid space (ie, the space that closely surrounds the brain)—the latter is known as a subarachnoid aneurysm hemorrhage. This is followed by one or more of the following symptoms: nausea, vomiting, double vision, stiff neck, and loss of consciousness. Subarachnoid aneurysm hemorrhage is an emergency medical condition that requires immediate treatment. Indeed, 10-15% of patients with the condition die before reaching the hospital for treatment. More than 50% of patients with the condition will die within the first thirty days after bleeding. Of those patients who survive approximately half will suffer a permanent stroke. Some of these effusions occur one to two weeks after the vasospasm hemorrhage in the cerebral vessels induced by the subarachnoid hemorrhage. Aneurysms can also cause problems that are not related to bleeding although this is less common. For example, an aneurysm can form a blood clot in itself that can rupture from the aneurysm and be carried downstream where it has the potential to occlude an arterial branch causing a stroke (eg, an ischemic stroke). In addition, the aneurysm may also press against the nerves (this has the potential to result in paralysis or abnormal sensation in an eye or face) or the adjacent brain (this has the potential to result in seizures).
[006] Given the potentially fatal consequences of aneurysms, particularly brain aneurysms, the technique has addressed the treatment of aneurysms using various approaches.
[007] Generally, aneurysms can be treated from the outside of blood vessels using surgical techniques or from the inside using endovascular techniques (the latter are encompassed under the broad heading of intervention techniques (ie, non-surgical) ).
[008] Surgical techniques typically involve a craniectomy that requires creating an opening in the patient's skull through which the surgeon can insert instruments to operate directly on the brain. In one approach, the brain is retracted to expose the vessels from which the aneurysm originates and then the surgeon places a clip through the aneurysm's neck thereby preventing arterial blood from entering the aneurysm. If there is a clot in the aneurysm, the clip also prevents the clot from entering the artery and prevents a stroke from occurring. After correct clip placement, the aneurysm will be eliminated in a matter of minutes. Surgical techniques are the most common treatment for aneurysms. Unfortunately, surgical techniques to treat these conditions are considered major surgery involving high risk for the patient and require the patient to have resistance even to have a chance of surviving the procedure.
[009] As discussed above, endovascular techniques are non-surgical techniques and are typically performed in a series of angiography using a catheter delivery system. Specifically, known endovascular techniques involve using a catheter delivery system to seal the aneurysm with a material that prevents arterial blood from entering the aneurysm—this technique is widely known as embolization. An example of such an approach is the Guglielmi Detachable Coil, which involves intra-aneurysm occlusion of the aneurysm through a system that uses a platinum coil attached to a stainless steel distribution wire and electrolyte release. In this way, after the platinum coil has been placed in the aneurysm, it is detached from the stainless steel distribution wire by electrolytic dissolution. Specifically, the patient's blood and saline infusion medium act as the conductive solutions. The anode is the stainless steel distribution wire and the cathode is the ground needle that is placed in the patient's groin. After current is transmitted through the stainless steel distribution wire, electrolytic dissolution will occur in the uninsulated section of the stainless steel release zone near the platinum coil (the platinum coil is, of course, unaffected by electrolysis). Other approaches involve using materials like cellulose acetate polymer to fill the aneurysm bag. Although these endovascular approaches are an advance in the technique, they are disadvantageous. Specifically, the risks of these endovascular approaches include rupturing the aneurysm during the procedure or causing a stroke (eg, an ischemic stroke) due to distal device embolization or clot from the aneurysm. Additionally, there is concern regarding the long-term results of endovascular aneurysm obliteration using these techniques. Specifically, there is evidence of intra-aneurysmal rearrangement of the sealing material and aneurysm reappearance on follow-up angiography.
[010] A specific type of brain aneurysm that has proven to be very difficult to treat, particularly using surgical clipping or endovascular embolization techniques discussed above occurs in the distal basilar artery. This type of aneurysm is a weak outward pocket formation, usually located at the terminal bifurcation of the basilar artery. Successful treatment of this type of aneurysm is very difficult due, at least in part, to the imperative requirement that all perforation vessels in the brainstem be spared during surgical clip placement.
[011] Unfortunately, there are times when the size, shape, and/or location of an aneurysm make both surgical clipping and endovascular embolization not possible for a specific patient. Generally speaking, the prognosis for such patients is not good.
[012] Therefore, although the prior art has made advances in the area of treating aneurysms, there is still room for improvement, particularly in endovascular embolization as it is such an attractive alternative to major surgery.
[013] In international publication number WO 99/40873 [Marotta et al. (Marotta]), published on August 19, 1999, a novel endovascular approach useful in blocking an aneurysm opening, particularly those in saccular aneurysms, is disclosed, leading to aneurysm obliteration. The approach is truly endovascular in that, with the stent revealed by Marotta, there is no requirement to seal the aneurysm sac with a material (for example, as used with the Guglielmi Detachable Coil). Rather, the stent disclosed by Marotta operates on the basis that it serves to block the opening to the aneurysm sac thereby avoiding the need for sealing material. Thus, the stent disclosed by Marotta is an important advance in the art as it avoids or alleviates many of the disadvantages of the prior art. The stent disclosed by Marotta comprises a sheet portion capable of being induced against the opening of the aneurysm thereby closing the aneurysm. In the stent disclosed by Marotta, the sheet sheet is attached to, and independently movable with respect to, a body comprising at least one expandable portion. The expandable portion is expandable from an unexpanded first state to a second expanded state with a radially outward force therein. Thus, the body serves the general purpose of securing the stent in place in a target body passageway or vascular lumen in the vicinity in which the aneurysm opening is located and the sheet portion serves the purpose of sealing the aneurysm opening of that way leading to aneurysm obliteration. Thereby, as revealed by Marotta, the leaf portion functions and moves independently of the body of the stent.
[014] Although the stent revealed by Marotta is a significant advance in the technique, there is still room for improvement. Specifically, in the preferred modality of the stent disclosed by Marotta, after the device is partially or fully implanted, for all intents and purposes, it is not possible to retrieve the stent - for example, for repositioning. While this may not be an issue in most cases, there are times where the doctor wants to be able to retrieve the device so that it can be repositioned for optimal placement.
[015] Therefore, there remains a need in the technique of an endovascular prosthesis that can be retrieved by the physician after it has been partially or fully implanted. It would be particularly advantageous to have a self-expanding stent that can be retrieved by the physician after being partially or fully implanted. Invention Summary
[016] It is an object of the present invention to avoid or lessen at least one of the aforementioned disadvantages of the prior art.
[017] It is another objective of the present invention to provide a new stent.
[018] It is another objective of the present invention to provide a new stent delivery device.
[019] Therefore, in one of its aspects, the present invention provides a stent comprising a first expandable portion, expandable from a first unexpanded state to a second expanded state to induce the first expandable portion against a vascular lumen; and A retractable sheet portion attached to the first expandable portion, the retractable sheet portion comprising at least one spine portion and a plurality of rib portions attached to the spine portion, longitudinally adjacent pairs of rib portions being free of interconnecting supports .
[020] In another of its aspects, the present invention provides a stent delivery device comprising a tubular element having a distal portion and a proximal portion, the distal portion having a porous surface defined by a plurality of circumferential rings, adjacent pairs of circumferential rings being interconnected by at least one longitudinal support, the porous surface comprising a circumferential width decreasing gradient of longitudinal support between longitudinal supports connected to opposite sides of a single circumferential ring in one direction from the proximal portion to the distal portion.
[021] In another of its aspects, the present invention provides a stent delivery device comprising a tubular element having a distal portion and a proximal portion, the distal portion having a porous surface defined by a plurality of circumferential rings, adjacent pairs of circumferential rings being interconnected by at least one longitudinal support, the porous surface comprising increasing porosity in a direction from the proximal portion to the distal portion.
[022] In a preferred embodiment, the porous surface of the delivery device comprises a cover layer, preferably made of a polymer and/or preferably substantially continuously disposed over the porous surface, to reduce friction between the delivery device and the inner surface of a delivery catheter, facilitating low force delivery of the stent. The nature of the cover layer will be described in more detail below.
[023] Thus, the present inventors have discovered a new stent that can be uncovered and covered again for repositioning the stent before the final implant of the same. This provides the physician with a significant advantage over the prior art devices described above. The present stent comprises a first expandable portion expandable from a first non-expandable state to a second expanded state to bias the first expandable portion against the wall of the vascular lumen like an artery. The stent further comprises a retractable sheet portion attached to the first expandable portion; the retractable leaf portion serves to facilitate stasis and thrombotic occlusion of the aneurysm. The retractable sheet portion comprises at least a spine portion and a plurality of rib portions attached to the spine portion. Importantly, longitudinally adjacent pairs of rib portions are free from intricately connected supports. The present inventors have carried out several tests and have found that when connections are made between adjacent rib portions, the retractability of the sheet portion is significantly compromised and, in many cases, the sheet portion may not be retracted.
[024] Furthermore, the present stent is advantageous in that it has a natural tendency to flex in such a way that the spine portion is on the outside of the curve. This is highly advantageous, especially when the device is implanted in a bifurcated body passage. An additional advantage is that the orientation of the rib portions, coupled to the flex, particularly facilitates atraumatic and accurate delivery and implantation of the present stent.
[025] Although not wishing to be bound by any specific theory or mode of action, it has been found that the rib portions of the present endovascular protease are compressible whereas the spine is not compressible; therefore under an axial load on the casing, the rib portions tend to compress and induce a curve that facilitates proper orientation during distribution in the correct direction.
[026] In a highly advantageous modality, the present stent is configured to be self-expanding. This means that the device can be coated or otherwise restrained prior to implantation and after initial delivery of the device, the coating or restriction is partially retracted thereby allowing the device to self-expand. This allows for partial and progressive implantation of the device with the advantage that the clinician can re-coat the device if the initial implantation of the stent is not in the correct position with respect to the patient's target anatomy. In this context, it is also possible to obtain an additional rotational orientation of the present stent by distributing the protest using a 'catheter that can be torqued'. This partially involves implanting the prosthesis to assess rotational orientation. If rotation of the device relative to the aneurysm neck needs to be adjusted, the prosthesis can be retracted into the catheter which can be torqued, torqued to the other orientation and then these steps are repeated until the prosthesis is considered as being in the correct position with respect to the aneurysm neck, after which the prosthesis can be fully uncovered and detached from the delivery device using various techniques such as those described in more detail below. This is another highly advantageous feature of the present stent.
[027] Another aspect of the present invention relates to the provision of a stent delivery device comprising the tubular element having a distal portion and a proximal portion. The distal portion of the stent has a porous surface composed of a number of circumferential rings with adjacent pairs of these rings being interconnected by one or more longitudinal supports. The porous surface on the distal portion of the stent delivery device has a decrease in width between a pair of longitudinal supports connected to opposite sides of a given circumferential ring. This decrease in longitudinal support circumferential width extends in one direction from the proximal portion of the tubular element to the distal portion of the tubular element. Consequently, this means that the distal portion of the tubular element becomes progressively more flexible in a direction towards the more distal end of the tubular element. This feature facilitates navigating the stent delivery device through tortuous anatomy while providing sufficient integrity and radial rigidity at the user end of the tubular element to be able to insert the device into the patient and navigate it fully to the target anatomy while avoiding or Decreases twist of the stent delivery device. In a preferred embodiment, there is a decrease in circumferential width between pairs of circumferential rings extending in a direction from the proximal portion to the distal portion.
[028] In a particularly preferred embodiment of the present stent delivery device, the circumferential rings comprise a series of alternating peaks and valleys. In this preferred embodiment, it is further preferred that the longitudinal supports connect a valley from a circumferential ring with a valley in an adjacent circumferential ring. This mode of connection called valley-valley is characterized by having the peaks in adjacent circumferential rings longitudinally aligned, but not connected. The advantage of this approach is that when the stent delivery device is flexed to some degree, the adjacent peaks will contact each other before the stent delivery device twists, over-flexing and deforming/breaking.
[029] The present stent is believed to be particularly useful in the treatment of aneurysms such as those described above and therefore is believed to provide a significant alternative to the conventional surgical techniques described above. Additionally, it is envisioned that the present stent may be used in the treatment of certain aneurysms that are diagnosed as being inoperable. The present stent is also believed to provide a significant advantage over current stent approaches such as the Guglielmi Detachable Coil described above. Specifically, since the present stent is not based on inserting a metal sealing material (eg, platinum coil) into the aneurysm, the risk of rupturing the aneurysm is diminished as is the risk of intra-aneurysm rearrangement of the material. of metal sealing and subsequent reappearance of the aneurysm. Of course, those skilled in the art will recognize that there may be certain situations where the present endovascular protease could be used in combination with the Guglielmi Detachable Coils described above - for example, to treat an aneurysm with a large peak in which a structure is added across the neck (this ie, the present stent) would help retain the coils within the aneurysm sac (this would prevent or lessen the possibility of a coil existing in the aneurysm sac and causing an ischemic stroke). Brief description of the drawings
[030] The embodiments of the present invention will be described with reference to the attached drawings, in which similar reference numerals indicate similar parts, and in which: Figure 1 illustrates a two-dimensional representation of a first embodiment of the present stent; Figure 1a is an enlarged view of a portion of Figure 1 identifying various elements in the design of the prosthesis; Figure 2 illustrates a perspective view of the stent shown in Figure 1; Figure 3 illustrates a top view of the stent shown in Figures 1-2 coupled to a delivery device; Figure 4 illustrates distribution of the stent shown in Figures 1-3 to occlude an aneurysm; Figures 5-6 illustrate a portion of the stent illustrated, in a transparent coating, in Figures 1-4 as it is reversibly coated and uncovered; Figure 7 illustrates the stent shown in Figures 1-6 after it has been released from the delivery device and is in the correct position to treat the aneurysm; Figure 8 illustrates the stent shown in Figures 1-7 after it has been implanted and is occluding an aneurysm (also, the delivery device is pulled away from the stent); Figure 9 illustrates a two-dimensional representation of a second embodiment of the present stent; Figure 10 illustrates a perspective view of the stent shown in Figure 9; Figure 11 illustrates a perspective view of the stent shown in figures 9-10 coupled to a delivery device; Figures 12(a)-12(c) illustrate details of how the stent illustrated in Figures 9-11 is coupled to the delivery device; Figure 13 illustrates a two-dimensional representation of a third embodiment of the present stent; Figure 14 illustrates a perspective view of the stent shown in Figure 13 as it is coupled to a delivery device; Figures 15(a)-15(d) illustrate additional detail of coupling the stent shown in Figures 13-14 to the delivery device; Figure 16 illustrates a two-dimensional representation of a fourth embodiment of the present stent; Figure 17 illustrates a perspective view of the stent shown in Figure 16; Figures 18-21 illustrate, in a stepwise fashion, implantation of the endovascular prosthesis illustrated in Figures 16-17 into an aneurysm located at the junction of a bifurcated artery; Figures 22-24 illustrate, in a stepwise fashion, the release of one end of the stent illustrated in Figures 16-21 from the delivery device; Figure 25 illustrates a perspective view of a portion of the delivery device used to deliver the stent illustrated in Figures 16-24; Figures 26-27 illustrate an enlarged view of the portion of the delivery device shown in Figure 25 and how it is coupled to an opposite end (as shown in Figures 22-24) of the stent shown in Figures 16-24; Figure 28 illustrates a two-dimensional representation of a fifth embodiment of the present stent; Figure 29 illustrates a perspective view of the stent shown in Figure 28; Figures 30-32 illustrate, in a stepwise mode, the release of the stent illustrated in Figures 28-29 from its delivery device; Figures 33-35 illustrate additional views of a delivery device used to deliver the stent illustrated in Figures 28-32; Figure 36 illustrates a two-dimensional representation of a sixth embodiment of the present stent; Figure 37 illustrates a perspective view of the stent shown in Figure 36 connected to a delivery device therefor; Figures 38(i)-(iii) illustrate a portion of a preferred embodiment of the present stent delivery device (including enlarged views in Figures 38(a)-(d)); and Figures 39-43 illustrate various views of various stent delivery devices that are shown throughout Figures 1-37. Detailed description of preferred modalities
[031] In one of its aspects, the present invention relates to an endovascular stent comprising: a first expandable portion, expandable from a first unexpanded state to a second expanded state to induce the first expandable portion against a vascular lumen ; and a retractable sheet portion attached to the first expandable portion, the retractable sheet portion comprising at least one spine portion and a plurality of rib portions attached to the spine portion, longitudinally adjacent pairs of rib portions being free of interconnecting supports . Preferred embodiments of such a stent may include any one or a combination of any two or more of any of the following features: . A single spine portion is connected to the first expandable portion; . The single spine portion comprises a row of rib portions connected on one side of the single spine portion; . The single spine portion comprises a pair of rows of rib portions, each row of rib portions connected to one side of the single spine portion; . The single spine portion comprises a pair of rows of rib portions connected to opposite sides of the single spine portion; . In two dimensions, each row of rib portions is a substantial mirror image of an adjacent row of rib portions along the single spine portion; . A first row of rib portions is connected at a plurality of first connection points to the single spine portion, and a second row of rib portions is connected to a plurality of second connection points to the single spine portion, the plurality of first connection points and the plurality of second connection points being longitudinally aligned in mutual relation; . A first row of rib portions is connected to a plurality of first connection points to the single spine portion, and a second row of rib portions is connected to a plurality of second connection points to the single spine portion, the plurality of the first connection points and the plurality of second connection points being longitudinally spread in mutual relation; . The single spine portion is linear; . The single spine portion is curvy; . The single spine portion is curved; . The single spine portion comprising an undulating pattern comprising alternating peaks and valleys; . At least some rib portions are connected to the peaks in the ripple pattern; . Each rib portion is connected to a peak in the ripple pattern; . In two dimensions, each rib portion is substantially configured to form an acute angle with respect to a spine longitudinal axis of the single spine portion; . In two dimensions, each rib portion comprises a proximal rib portion, a distal rib portion and an intermediate rib portion disposed therebetween; . In two dimensions, each rib portion has a substantially constant circumferential width; . In two dimensions, each rib portion has a variable circumferential width; . In two dimensions, the intermediate rib portion has a circumferential width less than at least one of the proximal rib portion and the distal rib portion; . The intermediate rib portion has a smaller circumferential width than the proximal rib portion and distal rib portion; . The proximal rib portion has a circumferential width in the range of approximately 0.03 to approximately 0.3 mm; . The proximal rib portion has a circumferential width in the range of approximately 0.04 to approximately 0.24 mm; . The proximal rib portion has a circumferential width in the range of approximately 0.0024 to approximately 0.24 mm; . The proximal rib portion is approximately 1% to approximately 10% of the overall length of the rib portion; . The proximal rib portion is approximately 2% to approximately 6% of the overall length of the rib portion; . The proximal rib portion is approximately 3% of the overall length of the rib portion; . The intermediate rib portion has a circumferential width in the range of approximately 0.01 to approximately 0.25 mm; . The intermediate rib portion has a circumferential width in the range of approximately 0.03 to approximately 0.16 mm; . The intermediate rib portion has a circumferential width in the range of approximately 0.04 to approximately 0.06 mm; . The intermediate rib portion is approximately 25% to approximately 90% of the overall length of the rib portion; . The intermediate rib portion is approximately 60% to approximately 90% of the overall length of the rib portion; . The intermediate rib portion is approximately 90% of the overall length of the rib portion; . The distal rib portion has a circumferential width in the range of approximately 0.03 to approximately 0.3 mm; . The distal rib portion has a circumferential width in the range of approximately 0.03 approximately 0.18 mm; . The distal rib portion has a circumferential width in the range of approximately 0.04 to approximately 0.06 mm; . The distal rib portion is up to approximately 25% of the overall length of the rib portion; . The distal rib portion is approximately 5% to approximately 16% of the overall length of the rib portion; . The distal rib portion is up to approximately 7% of the overall length of the rib portion; . The proximal rib portion is configured to form an acute angle of the proximal rib portion with respect to a longitudinal geometric axis of the stent; . The acute angle of the proximal rib portion is in the range of approximately 15° to approximately 90°; . The acute angle of the proximal rib portion is in the range of approximately 35° to approximately 60°; . The acute angle of the proximal rib portion is approximately 45°; . The distal rib portion is configured to form an angle of the distal rib portion with respect to an intermediate rib portion of the stent; . The angle of the distal portion of the rib is in the range of approximately 0° to approximately 120°; . The angle of the distal portion of the rib is in the range of approximately 3° to approximately 60°; . The angle of the distal portion of the rib is approximately 8°; . The intermediate rib portion is configured to form an acute angle of the intermediate rib portion with respect to a longitudinal geometric axis of the stent; . The acute angle of the mid-rib portion is in the range of approximately 5° to approximately 140°; . The acute angle of the mid-rib portion is in the range of approximately 22° to approximately 86°; . The acute angle of the mid-rib portion is approximately 45°; . The intermediate rib portion comprises: (i) a first intermediate rib portion connected to the proximal rib portion and configured to form an acute angle of the first intermediate rib portion with respect to a longitudinal geometric axis of the stent; and (ii) a second intermediate portion connected to the distal rib portion and configured to form an acute angle of the second intermediate rib portion with respect to a longitudinal geometric axis of the stent; . The acute angle of the first intermediate rib portion is smaller than the acute angle of the second intermediate rib portion; . The acute angle of the first intermediate rib portion is in the range of approximately 5° to approximately 140°; . The acute angle of the first intermediate rib portion is in the range of approximately 22° to approximately 66°; . The acute angle of the first intermediate rib portion is approximately 30°; . The acute angle of the second intermediate rib portion is in the range of approximately 5° to approximately 140°; . The acute angle of the second intermediate rib portion is in the range of approximately 42° to approximately 86°; . The acute angle of the second intermediate rib portion is approximately 60°; . The first intermediate rib portion has a circumferential width in the range of approximately 0.0010 to approximately 0.0100 inch; . The first intermediate rib portion has a circumferential width in the range of approximately 0.0014 to approximately 0.0062 inch; . The first intermediate rib portion has a circumferential width in the range of approximately 0.0018 to approximately 0.0024 inch; . The first intermediate rib portion is approximately 5% to approximately 25% of the overall length of the rib portion; . The first intermediate rib portion is approximately 7% to approximately 17% of the overall length of the rib portion; . The first intermediate rib portion is approximately 9% of the overall length of the rib portion; . The second intermediate rib portion has a circumferential width in the range of approximately 0.04 to approximately 0.18 mm; . The second intermediate rib portion has a circumferential width in the range of approximately 0.03 to approximately 0.11 mm; . The second intermediate rib portion has a circumferential width in the range of approximately 0.04 to approximately 0.05 mm; . The second intermediate rib portion is approximately 25% to approximately 90% of the overall length of the rib portion; . The second intermediate rib portion is approximately 53% to approximately 85% of the overall length of the rib portion; . The second intermediate rib portion is approximately 81% of the overall length of the rib portion; . In two dimensions, the distal rib portion of each rib portion is directed away from the first expandable portion; . In two dimensions, the distal rib portion of each rib portion is directed towards the first expandable portion; . In two dimensions, each rib portion is linear; . In two dimensions, each rib portion is curvilinear; . In two dimensions, each rib portion is curved; . In two dimensions, each rib portion comprises at least two sub-portions each sub-portion forms a different angle with respect to a longitudinal geometric axis of the stent; . A pair of longitudinally adjacent rib portions are spaced apart at a point of connection with the spine portion by a distance ranging from approximately 0.0254 mm to approximately 10 mm; . A pair of longitudinally adjacent rib portions are spaced apart at a point of connection with the spine portion by a distance ranging from approximately 0.0254 mm to approximately 5 mm; . A pair of longitudinally adjacent rib portions are spaced apart at a point of connection with the spine portion by a distance ranging from approximately 0.1400 mm to approximately 3 mm; . A pair of longitudinally adjacent rib portions are spaced apart at a point of connection with the spine portion by a distance ranging from approximately 0.1400 mm to approximately 1 mm; . A pair of longitudinally adjacent rib portions are spaced apart at a point of connection with the spine portion by a distance ranging from approximately 0.1400 mm to approximately 0.8 mm; . A pair of longitudinally adjacent rib portions are spaced apart at a point of connection with the spine portion by a distance ranging from approximately 0.1400 mm to approximately 0.6 mm; . A pair of longitudinally adjacent rib portions are spaced at a point of connection with the spine portion at a distance of approximately 0.254 mm; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy less than approximately 75% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy from approximately 5% to approximately 75% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy from approximately 5% to approximately 65% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy from approximately 10% to approximately 50% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy from approximately 55% to approximately 40% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy less than approximately 10% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy less than approximately 8% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy less than approximately 5% of a surface area of the retractable sheet portion; . In two dimensions, at least one spine portion and the plurality of rib portions attached to the spine portion combine to occupy less than approximately 3% of a surface area of the retractable sheet portion; . The retractable sheet portion further comprises a cover layer connected to the plurality of rib portions; . The retractable sheet portion comprises less than 10 longitudinally spaced rib portions connected on one side of the spine portion; . The retractable sheet portion comprises less than 8 longitudinally spaced rib portions connected on one side of the spine portion; . The retractable sheet portion comprises less than 6 longitudinally spaced rib portions connected on one side of the spine portion; . The retractable sheet portion contains only 3 longitudinally spaced rib portions connected on one side of the spine portion; . The ratio of the perpendicular distance from the longitudinal axis to the distal tip portion of the rib portion to 50% of the circumference of the first expandable portion in the second expanded state is in the range of approximately 1:4 to approximately 1:1; . In two dimensions, the ratio of the perpendicular distance from the longitudinal axis to the distal tip portion of the rib portion to 50% of the circumference of the first expandable portion in the second expanded state is in the range of approximately 1:2.5 to approximately 1:1.5; . In two dimensions, the ratio of the perpendicular distance from the longitudinal axis to the distal tip portion of the rib portion to 50% of the circumference of the first expandable portion in the second expanded state is approximately 5:9; . At least a portion of the spine is curved about a transverse geometric axis to a longitudinal axis of the stent; . At least a portion of the spine is curved about a geometric axis substantially orthogonal to a longitudinal axis of the stent; . The geometric axis is opposite the plurality of rib portions with respect to at least one spine portion; . At least one spine portion comprises a first radius of curvature with respect to the length of the at least one spine portion about a geometric axis transverse to a longitudinal geometric axis of the stent; . The first radius of curvature is substantially constant from a proximal portion of at least one spine portion to a distal portion of at least one spine portion; . The first radius of curvature is variable from a proximal portion of at least one spine portion to a distal portion of at least one spine portion; . The first radius of curvature decreases from a proximal portion of at least one spine portion to a distal portion of at least one spine portion; . The retractable sheet portion comprises a second radius of curvature with respect to the length of at least one spine portion about a longitudinal geometric axis of the stent; . The second radius of curvature is substantially constant from a proximal portion of the retractable portion to a distal portion of the retractable portion; . The second radius of curvature is variable from a proximal portion of the shrinkable sheet portion to a distal portion of the shrinkable sheet portion; . The second radius of curvature increases from a proximal portion of the shrink sheet portion to a distal portion of the shrink sheet portion; . In an expanded configuration of the stent, the retractable sheet portion comprises an arc of curvature about a longitudinal geometric axis of the stent in the range of approximately 90° to approximately 360°; . In an expanded configuration of the stent, the retractable sheet portion comprises an arc of curvature about a longitudinal geometric axis of the stent in the range of approximately 120° to approximately 270°; . The first radius of curvature is variable from a proximal portion of at least one spine portion to a distal portion of at least one spine portion; . The first radius of curvature decreases from a proximal portion of at least one spine portion to a distal portion of at least one spine portion; . The retractable sheet portion comprises a second radius of curvature with respect to the length of at least one spine portion about a longitudinal geometric axis of the stent; . The second radius of curvature is substantially constant from a proximal portion of the retractable portion to a distal portion of the retractable portion; . The second radius of curvature is variable from a proximal portion of the shrinkable sheet portion to a distal portion of the shrinkable sheet portion; . The second radius of curvature increases from a proximal portion of the shrink sheet portion to a distal portion of the shrink sheet portion; . In an expanded configuration of the stent, the retractable sheet portion comprises an arc of curvature about a longitudinal geometric axis of the stent in the range of approximately 90° to approximately 360°; . In an expanded configuration of the stent, the retractable sheet portion comprises an arc of curvature about a longitudinal geometric axis of the stent in the range of approximately 120° to approximately 270°; . In an expanded configuration of the stent, the retractable sheet portion comprises an arc of curvature about a longitudinal geometric axis of the stent in the range of approximately 150° to approximately 250°; . In an expanded configuration of the stent, the retractable sheet portion comprises an arc of curvature about a longitudinal geometric axis of the stent in the range of approximately 175° to approximately 225°; . In an expanded configuration of the stent, the retractable sheet portion comprises an arc of curvature around a longitudinal geometric axis of the stent of approximately 200°; . The first expandable portion has a diameter in the second expanded state in the range of approximately 2 mm to approximately 40 mm; . The first expandable portion has a diameter in the second expanded state in the range of approximately 2 mm to approximately 30 mm; . The first expandable portion has a diameter in the second expanded state in the range of approximately 2 mm to approximately 20 mm; . The first expandable portion has a diameter in the second expanded state in the range of approximately 2 mm to approximately 10 mm; . The first expandable portion has a diameter in the second expanded state in the range of approximately 2.5 mm to approximately 5 mm; . A single spine portion is connected to the first expandable portion and a loop portion is connected to a distal portion of the single spine portion; . A single spine portion is connected to the first expandable portion and a split loop portion connected to a distal portion of the single spine portion; . The loop portion comprises a radiopaque portion; . The stent further comprises a second expandable portion, expandable from a first unexpanded state to a second expanded state to bias the first expandable portion against a vascular lumen; . The second expandable portion comprises a radiopaque portion; . The stent is manufactured from a tubular starting material; . The stent is manufactured from a tubular starting material on which a cutting technique has been applied; . The stent is manufactured from a tubular starting material on which a laser cutting technique has been applied; . The tubular wall has a radial thickness in the range of approximately 0.01 to approximately 0.51 mm; . The tubular wall has a radial thickness in the range of approximately 0.04 to approximately 0.25 mm; . The tubular wall has a radial thickness of approximately 0.06 mm; . The first expandable portion comprises a radiopaque portion; . The prosthesis is constructed of a self-expanding material; . The prosthesis is constructed from a shape memory alloy; . The prosthesis is constructed of nitinol; . The prosthesis is constructed of a metallic material; and/or . The prosthesis is constructed of a polymer material. .
[032] In one of its aspects, the present invention relates to a stent delivery device comprising a tubular element having a distal portion and a proximal portion, the distal portion having a porous surface defined by a plurality of circumferential rings, adjacent pairs of circumferential rings being interconnected by at least one longitudinal support, the porous surface comprising a circumferential width decrease gradient of longitudinal support between longitudinal supports connected to opposite sides of a single circumferential ring in a direction from the proximal portion to the distal portion. Preferred embodiments of such a stent delivery device may include any one or a combination of any two or more of any of the following features: . Each circumferential ring comprises alternating peaks and valleys; . At least one longitudinal support connects a first valley in a first circumferential ring to a second valley in a second circumferential ring adjacent to the first circumferential ring; . At least one longitudinal support connects to a midpoint of the first valley; . At least one longitudinal support connects to a midpoint of the second valley; . At least one longitudinal support connects to: (i) a midpoint of the first valley, and (ii) a midpoint of the second valley; . The first circumferential ring and the second circumferential ring individually comprise at least one pair of alternating peaks and valleys; . The first circumferential ring and the second circumferential ring each comprise at least two pairs of alternating peaks and valleys; . The stent delivery device comprises a longitudinal support for each peak; . The stent delivery device comprises a longitudinal support for each valley; . The stent delivery device comprises a longitudinal support for each pair of alternating peaks and valleys in the first circumferential ring or second circumferential ring; . The first circumferential ring and the second circumferential ring individually comprise a pair of alternating peaks and valleys; . Two longitudinal supports interconnect the first circumferential ring and the second circumferential ring; . The plurality of circumferential rings comprise a first circumferential ring, a second circumferential ring axially spaced from the first circumferential ring, and a third circumferential ring axially spaced from the second circumferential ring; . First circumferential ring and third circumferential ring are spaced apart a distance that is in the range of approximately 100% to approximately 300% of the diameter of the tubular element; . First circumferential ring and third circumferential ring are spaced apart a distance that is in the range of approximately 175% to approximately 225% of the diameter of the tubular member; . First circumferential ring and third circumferential ring are spaced apart a distance that is approximately 200% of the diameter of the tubular element; . The porous surface has a proximal porous portion and a distal porous portion disposed distally from the proximal porous portion; . The stent delivery device comprises a first longitudinal support disposed on the distal porous portion and a second longitudinal support disposed on the proximal porous portion, with the proviso that a first circumferential longitudinal support width of the first longitudinal support is smaller. than a second longitudinal support circumferential width of the second longitudinal support; . The first circumferential longitudinal support width and the second circumferential longitudinal support width are individually in the range of approximately 0.03 mm to approximately 12.7 mm; . The first circumferential longitudinal support width and the second circumferential longitudinal support width are individually in the range of approximately 0.89 mm to approximately 7.62 mm; . The first circumferential longitudinal support width and the second circumferential longitudinal support width are individually in the range of approximately 0.11 mm to approximately 0.38 mm; . The first circumferential longitudinal support width is greater than approximately 0.03 mm and the second circumferential longitudinal support width is less than approximately 1.27 mm; . The first circumferential longitudinal support width is greater than approximately 0.09 mm and the second circumferential longitudinal support width is less than approximately 0.76 mm; . The first circumferential longitudinal support width is greater than approximately 0.11 mm and the second circumferential longitudinal support width is less than approximately 0.38 mm; . The stent delivery device comprises a first circumferential ring disposed on the distal porous portion and a second circumferential ring disposed on the proximal porous surface, with the proviso that a first axial width of the first circumferential ring is less than a second axial width of the second circumferential ring; . The first axial width and the second axial width are individually in the range of approximately 0.03 mm to approximately 1.14 mm; . The first axial width and the second axial width are individually in the range of approximately 1.02 mm to approximately 8.25 mm; . The first axial width and the second axial width are individually in the range of approximately 3.05 mm to approximately 0.64 mm; . first axial width is greater than approximately 0.03 mm and the second axial width is less than approximately 1.14 mm; . The first axial width is greater than approximately 1.02 mm and the second axial width is less than approximately 0.82 mm; . The first axial width is greater than approximately 1.27 mm and the second axial width is less than approximately 0.64 mm; . Stent delivery device comprises a first pair of adjacent circumferential rings disposed on the distal porous portion and a second pair of circumferential rings disposed on the proximal porous surface, with the proviso that a first minimum distance between the first pair of adjacent circumferential rings is greater than a second minimum distance between the second pair of adjacent circumferential rings; . Both the first minimum distance and the second minimum distance are in the range of approximately 0.03 mm to approximately 0.64 mm; . Both the first minimum distance and the second minimum distance are in the range of approximately 0.006 mm to approximately 0.48 mm; . Both the first minimum distance and the second minimum distance are in the range of approximately 1.02 mm to approximately 0.38 mm; . The first minimum distance is less than approximately 0.64 mm and the second minimum distance is greater than approximately 0.03 mm; . The first minimum distance is less than approximately 0.48 mm and the second minimum distance is greater than approximately 0.06 mm; . The first minimum distance is less than approximately 0.38 mm and the second minimum distance is greater than approximately 0.11 mm; . The stent delivery device comprises a first pair of adjacent circumferential rings disposed on the distal porous portion and a second pair of circumferential rings disposed on the proximal porous surface, with the proviso that a first maximum distance between the first pair of adjacent circumferential rings is greater than a second maximum distance between the second pair of adjacent circumferential rings; . Both the first maximum distance and the second maximum distance are in the range of approximately 1.27 mm to approximately 1.02 mm; . Both the first maximum distance and the second maximum distance are in the range of approximately 0.19 mm to approximately 0.93 mm; . Both the first maximum distance and the second maximum distance are in the range of approximately 0.23 mm to approximately 0.84 mm; . The first minimum distance is less than approximately 1.02 mm and the second minimum distance is greater than approximately 0.13 mm; . The first minimum distance is less than approximately 0.93 mm and the second minimum distance is greater than approximately 0.19 mm; . The first minimum distance is less than approximately 0.84 mm and the second minimum distance is greater than approximately 0.23 mm. The stent delivery device further comprises a stent connecting portion attached to the distal portion; . The stent connecting portion comprises at least one elongated section comprising an intermediate section and a distal section for connecting to the stent; . At least one of the intermediate section and distal section are inclined with respect to a longitudinal geometric axis of the stent delivery device; . Both the mid-section and the distal section are slanted with respect to a longitudinal geometric axis of the stent delivery device; . The middle section and the distal section are slanted in relation to each other; . The stent connecting portion comprises a pair of elongated sections comprising a first elongated section and a second elongated section; . The first elongated section comprises a first stent fixation portion disposed at a distal end thereof; . The first stent fixation portion comprises a first half of a first male-female connection system for receiving a second half of the first male-female connection system disposed in a stent; . The first half of the male-female connection system comprises a first male portion; . The second half of the first male-female connection system comprises a first female portion; . The first half of the male-female connection system comprises a first female portion; . The second half of the first male-female connection system comprises a first male portion; . The first half of the first male-female connection is configured to receive a first stent release element; . The second half of the first male-female connection is configured to receive a first stent release element; . The first half and second half of the first male-female connection are configured to receive a first stent release element; . The first stent release element comprises a first thread element; . The second elongated section comprises a second stent fixation portion disposed at a distal end thereof; . The second stent fixation portion comprises a first half of a second male-female connection system for receiving a second half of the second male-female connection system disposed in a stent; . The first half of the second male-female connection system comprises a second male portion; . The second half of the second male-female connection system comprises a second female portion; . The first half of the second male-female connection system comprises a second female portion; . The second half of the second male-female connection system comprises a second male portion; . The first half of the second male-female connection is configured to receive a second stent release element; . The second half of the second male-female connection is configured to receive a second stent release element; . The first half and second half of the second male-female connection are configured to receive a second stent release element; . The stent release element comprises a thread element; . The first elongated portion has a longer longitudinal length than the second elongated portion; . The second elongated portion has a greater longitudinal length than the first elongated portion; and/or . The first elongated portion and the second elongated portion are of substantially equal longitudinal length.
[033] Referring to Figures 1-2, a stent 100 is illustrated. The stent 100 comprises an expandable portion 105, a sheet portion 110 and a loop portion 115. The expandable portion 105 comprises a pair of cir rings - corrugation abutments 106,107 which are interconnected to each other by a pair of longitudinal supports 108, 109.
[034] The sheet portion 110 comprises a spine portion 111 to which a first row of rib portions 112 on one side thereof and a second row of rib portions 113 on an opposite side thereof are connected. As can be seen, portion 111 comprises a dimple configuration (see also Figure 1a for an enlarged view of this feature). Individual ribs in each of the rows 112, 113 are connected to the peaks of the dimple pattern formed by the spine portion 111. This results in the connection point of individual rib portions in rows 112, 113 being longitudinally displaced in relation to each other.
[035] The specifications for each portion of rib in rows 112 and 113 are preferred to be those mentioned above. Loop portion 115 comprises a single loop portion 116, the function of which will be described in more detail below.
[036] The stent 100 further comprises a series of radiopaque markers 120 arranged at various positions on the stent 100.
[037] The expandable portion 105 comprises a pair of loop portions 122, 124 for connecting to a distribution system (discussed below).
[038] Referring to Figure 1a, an enlarged view of a portion of endovascular device 100 is illustrated. The following is a concordance of terms used in Figure 1a (although the terms are illustrated with reference to endovascular device 100, the same also apply to endovascular devices 200, 300, 400, 500 and 600 described in more detail below) and elsewhere in this descriptive report:


[039] Referring to Figure 3, the stent 100 is connected to a delivery device 130. Details of the delivery device 130 will be discussed in further detail below. For present purposes, the delivery device 130 comprises at its distal end a pair of arms 130 (only one arm is shown in Figure 3). Each arm 135 of delivery device 130 is connected to loop portion 122 or 124 of expandable portion 105 as shown in Figure 3. A delivery catheter 140 covers delivery device 130.
[040] Referring to Figure 4, additional details are provided in connecting the delivery device 130 to the stent 100 and implanting the latter.
[041] Thus, the delivery device 130 comprises a porous tube 132 in the distal portion of which arms 135 can be found. One arm 135 is connected to loop 122 of the expandable portion 105 in a male-female arrangement while the other arm 135 it is connected to the loop portion 124 also in a male-female relationship. The connection between the arms 135 and the loop portions 122, 124 is maintained as shown in Figure 4 by a pair of wires 137.
[042] As shown in Figure 4, the stent 100 is provided to a body passageway 10 (i.e., an artery) having an aneurysm 15 with an aneurysm opening 17. In the illustrated embodiment, the stent 100 is a device called self-expansion. This means that when casing 140 is retracted, the stent 100 will expand to its unfolded state.
[043] In the illustrated modality, the stent 100 is incorrectly positioned with respect to the aneurysm 15, particularly the aneurysm opening 17. Specifically, the clinical goal is to have the sheet portion 115 that covers the aneurysm opening 17 of the aneurysm 15, finally leading to aneurysm occlusion 15. As shown in figure 4, the clinical goal was not achieved.
[044] One of the specific advantages of the present invention generically and the stent specifically is that the stent can be retracted into the sheath after it has been fully uncovered and before it is fully released and implanted. A device that is retracted and partially uncovered is shown schematically in figures 5 and 6, respectively.
[045] Thus, in Figure 5 the liner 140 is extended to cover the sheet portion 115 of the stent 100. Although, in the illustrated embodiment, the loop portion 116 emanates from the liner 140 in Figure 5, the entire device could be retracted into liner 140, if desired. The orientation and design of the rib portions in the sheet portion 115 facilitates the retraction of the sheet portion 105 into the liner 140, for example, by allowing for marking the distal portions of respective rib portions in rows 112, 113 - this is a particularly advantageous feature of the present stent in general.
[046] As shown in figure 5, the coating again of the stent 100 is obtained by relative movement between the stent 100 and the coating 140 in the direction of arrow A. when it is desired to discover the stent 100 (for the first time or otherwise mode), the liner 140 is moved relative to the stent in the direction of arrow B as shown in figure 6.
[047] The ability to coat, uncoat, re-coat, etc., stent 100 as shown in figures 5 and 6 is a distinct advantage of the present stent generically as it allows the clinician to optimize the position of the stent portion. sheet 115 in relation to aneurysm opening 17 of aneurysm 15, even after stent 100 has been partially or fully uncovered. In addition, the characteristic of coating, removing the coating, re-coating, etc., also allows the clinician to assess the size (diameter and length of the stent in relation to the patient's anatomy and if the sizing is not satisfactory the clinician can remove fully the stent and replace it with a device of the correct size while keeping the sheath on the patient in the target location.
[048] The optimal position of the stent 100 is shown in Figure 7 where the sheet portion 115 occludes the aneurysm opening 17 of the aneurysm 15. The term "occlude" is used in a broad sense and generically means that the portion of sheet 115 covers aneurysm opening 17 of aneurysm 15. While not wishing to be bound by any specific theory or mode of action, it is believed that this sheet portion 115 action creates a pressure drop between aneurysm 15 and the vessel of origin that finally leads to occlusion and healing. The single loop 116 of the loop portion 115 serves to improve the apposition of the sheet portion 110 in the body passage 10.
[049] After the stent 100 is in the correct position (this can be confirmed by the clinical use of conventional radiography and observation of the position of radiopaque markers 120 in relation to the target anatomy), the stent 100 is released from the delivery device 130. This is achieved by retracting wires 137 (initial retraction is shown in Figure 7) which allows arms 135 of delivery device 130 to be released from loops 122, 124 of expandable portion 105 of stent 100. Delivery device 130 and liner 140 can then be removed from the patient. Leaving the correctly deployed stent 100 implanted as shown in figure 8.
[050] With reference to figures 9 and 10, a stent 200 is illustrated. The stent 200 is similar to the stent 100 illustrated in figures 1-2 with the following exceptions: . Single closed loop 116 in loop portion 115 of stent 100 has been replaced with a pair of split loop portions 216a, 216b; . The arrangement of radiopaque markers 220 on the stent 200 differs from the arrangement of radiopaque markers 120 on the stent 100; . The design of the individual ribs in the sheet portion 210 of the stent 200 has been slightly modified with respect to the rib portions in the sheet portion 110 of the stent 100; . The rib portions in rows 212, 213 of stent 200 are more closely spaced than in stent 100; and . Loops 222 and 224 were modified to attach to the distribution system.
[051] The use of split loops 216a, 216b provides improved placement of the stent 200. A single loop 116 as used in the stent 100 may protrude into the lumen of the artery if the single loop is oversized for size of the artery. The split loop pair provision 216a, 216b allows overlapping of each loop in a given pair while avoiding flexion into the lumen of the artery. The addition of radiopaque markers in this modality facilitates visualization by the clinician of the location of the ends of the stent 200. The provision of radiopaque markers 220 on the expandable portion 205 as illustrated facilitates the visualization of one end, the end of the stent 200 while the provision of markers radiopaque tubes 220 in loop portion 215 as illustrated facilitates visualization of the other end of prosthesis 200.
[052] In addition, having two markers near the spine of the leaf and representing the length of the occlusive leaf length allows the clinician the ability to assess whether the leaf length relative to the aneurysm opening 17 is adequate.
[053] As can be seen, loop 222 comprises a pair of apertures 222a, 222b. Similarly, loop 224 comprises a pair of apertures 224a, 224b.
[054] Referring to Figure 11, the stent 200 is secured to a delivery device 230. As can be seen, the delivery device 230 comprises a porous tube 232. A pair of arms 235 is provided at the distal end of the tube. porous 232. Figure 12(a) provides an enlarged view of region C of Figure 11. As can be seen, each arm 235 has a pair of apertures 235a, 235b. Opening 235a of arm 235 is aligned with opening 222a or 224a of loops 222 or 224, respectively. Similarly, aperture 235b is aligned with apertures 222b or 224b of loops 222 or 224, respectively. A loop wire 240 is then passed through these aligned loops to create a pair of loops of wire 241. Loop wire 240 can be a single wire for each of the arms 235 or it can be a pair of independent wires. A release wire 245 is then fed through loops 241. This can be seen more clearly with reference to Figure 12(b) which illustrates the arrangement of loop wire 240 and release wire 245 without the detail of stent 200 or device 230. Figure 12(c) shows the orientation of loop wire 240 by itself.
[055] The stent 200 can be navigated to an aneurysm in the same manner as described above with reference to the stent 100. Thereby, the stent 200 also has a beneficial feature of being able to be coated, uncovered, re-coated, etc., as appropriate for stent 100.
[056] When the stent 200 is correctly positioned, it can be detached from the delivery device 230 by sequentially retracting the release wire 245 and then retracting the loop wire 240. As will be recognized by those skilled in the art, after the delivery wire release 245 is retracted, loops 241 are free to be retracted from the openings in loops 222, 224 and the openings in arms 235. After loops 241 have thereby retracted, stent 200 will disengage from arms 235 of delivery device 230 .
[057] Referring to Figures 13 and 14, a stent 300 is illustrated. The stent 300 is similar to the stent 200 described above with the exception that the expandable portion 305 has been modified. Specifically, expandable portion 305 comprises an anchor spine 306 with a series of anchor ribs 307 disposed on opposite sides of anchor spine 306.
[058] Another modification made to the stent 300 is the provision of a single loop 322 comprising a pair of openings 322a, 322b for connection to a delivery device.
[059] The advantages of stent 300 compared to stent 200 include: . A single fixation connection between the stent and delivery device compared to two connections for stent 200 (and stent 100); and . Addition of radiopaque markers near the rib tips near the middle of the sheet portion, which are generally circumferentially orthogonal to the markers near the spine portion of the sheet portion - these circumferentially orthogonal markers help the clinician to assess the rotational position of the device radiographically.
[060] With specific reference to Figures 14 and 15, the stent device 300 connected to a delivery device 330 having a porous tube 332 is illustrated. Disposed at the end of the porous tube 332 is a single arm 335. The arm 335 comprises a pair of openings which, during fabrication, can be aligned with openings 322a, 322b of loop 322 of stent 300. After these openings are aligned during fabrication, a single loop/release wire 345 is fed through the aligned openings to provide a pair of loops 341. The same loop/release wire 345 is then fed back on itself through loops 341 as shown in Figures 15(a), (b), (c) and (d) which provide various details of how the single loop/release wire 345 is positioned. As shown, the end of the single loop/release wire 345 is permanently affixed to the arm335.
[061] The stent 300 can be delivered to a target aneurysm in the same manner as described above with reference to the stent 100 and stent 200. After the stent is in the correct position, it can be detached from the delivery device 330 by retracting the loop/release wire 345. Initial retraction of loop/release wire 345 removes it from loops 341. Continued retraction of loop/release wire 345 removes loops 341 from the aligned openings in loop 322 of the stent 300 and arm 335 of delivery device 330. At that point, delivery device 330 may be withdrawn leaving stent 300 in place.
[062] The stent described above with reference to figures 1-15 is particularly well suited for occlusion of a so-called lateral wall aneurysm. Occasionally, the target aneurysm is located at an intersection of a bifurcated artery such as the distal basilar artery described above - such a target aneurysm is generally more difficult to treat than a sidewall aneurysm. For treatment of such a target aneurysm, it is preferred to further modify the stent described above with reference to Figures 1-15.
[063] Thus, with reference to Figures 16-17, a stent 400 is illustrated that is particularly well suited for treating an aneurysm located in a bifurcated artery. As can be seen, stent 400 is similar to stent 100 described above with reference to Figures 1-2 with the following modifications: . Expandable portion 405 (including circumferential rings 406, 407 and supports 408, 409) has been rotated to the opposite end of spine 411 so that spine 411 is connected to a circumferential ring peak 406 (as per spine 111 on stent 100 that is connected to a circumferential ring valley 106) - this feature facilitates distribution of the stent 400 in a straight or bifurcated body passage; . Release loops 422, 424 are located at opposite ends of stent 400 (as per loops 122, 124 located in expandable portion 105 of stent 100); . There is no loop portion at the proximal end of the stent 400 as there is a stent 100 (as per the loop portion 115); and . A single fixation portion 424 is provided at a proximal end of the spine 411 of the stent 400.
[064] Referring to Figures 18-21, distribution and deployment of the stent 400 in a bifurcated artery 50 is illustrated. As can be seen, the bifurcated artery 50 comprises an aneurysm 55 having an aneurysm opening 57.
[065] Of specific note in Figures 18-21 is the general way in which the stent is oriented during distribution and deployment. Specifically, when any of the stents 100, 200, 300 described above is delivered to a sidewall aneurysm, delivery is accomplished by orienting the expandable portion (105, 205, 305) such that it is close to the clinician's step. that the snare portion (115, 215, 315) is oriented distally to the clinician thereby exiting first from delivery catheter 440. Conversely, when delivering stent 400 to bifurcated artery 50, expandable portion 405 is oriented distally to the clinician whereas loop 424 (at the opposite end of the stent relative to the expandable portion 405) is oriented closely to the clinician thereby exiting last from delivery catheter 440.
[066] With reference to Figure 18(a), a guidewire 66 is inserted and passed through a first branch 51 of the bifurcated artery 50. Next, with reference to Figure 18(b), the delivery liner/catheter 440 is passed over guide wire 66 into first branch 51 of bifurcated artery 50.
[067] Next, with reference to figure 18(c), the guidewire 66 is removed from the first branch 51 of the bifurcated artery 50. With reference to figure 18(d) the stent 400 fixed to the delivery device 430 is fed through delivery liner/catheter 440 until stent 400 is positioned in first branch 51 of bifurcated artery 50.
[068] Referring to Figure 18(e) the delivery casing/catheter 440 is subsequently retracted; this results in initial deployment of the expandable portion 405 of the stent 400. If the physician is not satisfied with this initial deployment of the expandable portion 405 of the stent 400, he/she may re-coat the stent 400 in an attempt to reposition the same in the first branch 51 of the bifurcated artery 50.
[069] After the clinician is satisfied with the initial deployment of the stent 400, the delivery liner/catheter 440 is further retracted exposing the proximal portion of the stent 400 - see Figure 18(f).
[070] Referring to Figure 19, the delivery device 430 is further extended as shown in Figure 19. This additional extension naturally progresses into a second branch 52 of the bifurcated artery 50 due to the initial deployment of the stent 400.
[071] After it has been determined that the stent 400 is in the correct position, the delivery device 430 is detached from the stent 400 in the manner to be discussed below. This allows for removal of delivery catheter 440 and delivery device 430 resulting in final deployment of stent 400 as shown in Figure 21. In this final deployed configuration, sheet portion 410 of stent 400 includes aneurysm opening 57 of aneurysm 55 .
[072] Referring to Figure 25, a delivery device 430 for delivering stent 400 is illustrated. Delivery device 430 comprises a porous surface 432 similar to that described above with reference to stent 100, 200, 300. manifold 430 further comprises a first arm 435 having a square opening 437 and a second arm 442 having a shim/shim attachment 445. The shim/shim attachment 445 comprises a finger portion 447 having an opening 448. The finger portion 447 is movable with respect to a pleat/shim fixation protective portion 449 445. The pleat/shim fixation protective portion 449 445 protects against obstruction of loop 424 during retraction of stent 400.
[073] Referring to Figures 22-24, additional detail is illustrated in attaching the arm 435 of the delivery device 430 to the loop portion 424 of the expandable portion 405 of the stent 400. Thereby, the loop portion 424 is inserted into the square opening 437 and a wire 438 is inserted through loop portion 424 to secure loop portion 424 with respect to square opening 437 - see Figure 22. After the stent is in the correct position and the clinician wishes to detach the delivery device 430 from the stent 400, the wire 438 is retracted as shown in Figure 23. This allows the arm 435 to be separated from the loop portion 424 of the stent 400 as shown in Figure 24.
[074] Referring to Figures 26 and 27, additional detail of attachment of the attachment portion 422 of the stent 400 to the crease/shim attachment 445 of the arm 442 of the delivery device 430 is illustrated - for ease of understanding the illustration has been made outside the vasculature (as shown in figure 20). Thereby, the finger portion 447 of the pleat/shim attachment 445 is inserted into a first opening 426 of the attachment portion 422. A wire 428 is inserted through a second opening 429 of the attachment portion 422 such that it also passes through the opening portion 448 of the crease/shim fixation finger portion 447 445 - see Figure 27. This arrangement serves to secure the fixation portion 422 of the stent 400 with respect to the fold/shim fixation 445 of the stent device. distribution 430.
[075] When the stent 400 is in the correct position and the clinician wishes to detach the stent 400 from the delivery device 430, the clinician retracts the wire 428 from the openings 429, 448. This allows the finger portion 447 to be able to be retracted from opening 426 of fixation portion 422 thereby allowing disengagement of that portion of stent 400 from delivery device 430.
[076] At this point, the delivery device 430 is detached from the stent 400 and the former can be fully retracted from the patient through the delivery liner/catheter 440 as shown in figure 20. The final deployment of the stent 400 is illustrated in Figure 21.
[077] Referring to Figures 28-35, a stent 500 is illustrated that is particularly well suited for treating an aneurysm located in a bifurcated artery. As can be seen, stent 500 is similar to stent 400 described above with reference to Figures 16-17 with the following general modifications: . The provision of arms 519; . The single radiopaque marker 420 on the stent 400 was replaced with a trio of radiopaque markers 520a, 520b, 520c; . The arrangement of radiopaque markers 520 in rows 512, 513 of the rib portions was altered; . A single attachment portion 430 provided at the end of the spine 411 of the stent 400 has been replaced by an arm 519 at the end of which is an attachment portion 524 comprising a pair of apertures 526, 529.
[078] Several technical effects arise from these modifications. The additional radiopaque markers provide the clinician with information about the location in the patient of the proximal and distal ends of the stent 500. In the stent 400, the radiopaque markers were arranged along the same side of the spine portion of the stent. In contrast, in a 500 stent, the radiopaque markers alternate along the portion of the spine and the nearest radiopaque marker is centered with the spine. The pair of arms 519 on the stent 500 serve to drive the spine and rib portions toward the aneurysm opening and provide support for the spine and rib portions to bias them against the artery wall. In addition, the pair of arms 519 replaces the function of the second arm 442 of the delivery device used in the stent 400.
[079] Referring to Figures 30-35, the attachment of the stent 500 to a delivery device 530 which is similar to the delivery device 430 described above is illustrated. One difference is that first arm 435 of delivery device 430 has been replaced with a first portion of wire 535 which is fed into loop portion 524 of expandable portion 505. A wire 538 is fed through portion of wire 535 as shown in Figure 30 illustrating the attachment of the delivery device 530 to the expandable portion 505. When it is desired to disengage the wire portion 535 from the expandable portion 505, the wire 538 is retracted which allows the wire portion 535 to disengage from the portion of loop 524 of expandable portion 505 - see figures 31 and 32.
[080] Referring to figure 33, additional detail is shown on the delivery device 530. In essence, the arms 435, 442 used in stent 400 have been omitted. Specifically, arm 435 has been replaced with the portion of wire 535 and arm 442 has been omitted and replaced with a pair of arms 519 on stent 500 - see Figure 34. The function of arm 442 is replaced by the presence of arms 519 on the stent 500 with the added advantage that the curvature in arms 519 on the stent 500 aids in the correct placement of the stent 500 into a bifurcated artery.
[081] As shown, delivery device 530 comprises a securing portion 542 that is aligned with openings 526, 529 of arms 519 of stent 500 and secured as a unit by a loop wire 548 and a release wire 528 As shown in Figure 34, the arms 519 of the stent 500 are aligned such that the respective openings 526, 529 of each arm 519 are aligned. Loop wire 548 is passed through fastening portion 542 of dispensing device 530. A retraction wire 528 is passed through loop wire 548 as shown in Figure 34 and also as shown in Figure 35.
[082] The stent 500 may be provided using the delivery device 530 in a manner similar to that described above in figures 18-21 with reference to the stent 400.
[083] With reference to Figures 36 and 37, an endovascular stent 600 is illustrated that is particularly well suited for treating aneurysm located in a bifurcated artery. As can be seen, the stent 600 is similar to the stent 500 described above with reference to Figures 28 and 29 with the following general modifications: . Pair of 519 arms on 500 stent was replaced with a quartet of 619 arms; . Radiopaque markers 620 are disposed differently on stent 600 than radiopaque markers 520a, 520b, 520c, 520d on stent 500; . The longitudinal support 509 has been eliminated, thereby resulting in the element 606, 607 being non-circumferentially extended (may be considered as so-called "split loops"); and . An element corresponding to the attachment point 522 does not exist in the stent 600 because the "expandable portion" has been replaced with ribs or split loops and as such, no longer requires an attachment point.
[084] One of the main advantages of the stent 600 is that it can be delivered with a delivery device 630 which consists of a single attachment to the stent 600. The provision of arms 619 will improve induction of the spine portion and rib portions against the aneurysm opening and against the artery wall. This is particularly advantageous as it allows stent implantation in more varied anatomy than the stent 500. If the stent 600 is oversized relative to the target artery, the arms 619 will remain against the artery wall and will overlap mutually, whereas in stent 500, arms 519 may invade the lumen of the artery if the stent were oversized. A similar advantage results with reference to elements 606 and 607. Finally there are radiopaque markers arranged on both sides of the spine portion in the stent 600 compared to the alternate arrangement used in the stent 500 - this provides a more detailed description of the leaf spine radiographically that allows optimal positioning in relation to the opening of the aneurysm.
[085] Figure 37 illustrates connection of the stent 600 to the delivery device 630. Specifically, the fixation portion 622 of the stent 600 is aligned with a fixation portion 632 of the delivery device 630. 600 to delivery device 630 are not illustrated in Figure 37, it is preferred to use a single release wire/loop as described above with reference to Figures 14 and 15 with the proviso that loops 341 are reversed when connecting the stent 600 to the distribution device 630.
[086] Referring to Figures 38(i)-38(iii), various views of the distal portion of a stent delivery device 5 are illustrated. The illustrated distal portion has a porous surface. The remainder of the stent delivery device (not shown for clarity) is substantially non-porous.
[087] As illustrated, there is a general increase in porosity of the porous surface of the stent delivery device 5 moving from a proximal portion of the porous surface to the distal portion of the porous surface (left to right in Figures 38(i) -(iii)).
[088] The present inventors have found that a combination of specific dimensions of the porous surface is particularly useful in providing a highly desirable balance between longitudinal flexibility and sufficient structural integrity (ref. Torque Submitability) to facilitate the delivery of a stent, particularly through tortuous vascular.
[089] Specifically, with specific reference to Figures 38(a) and 38(b), a functional advantage resulting from a porous surface having the combination of dimensions is to allow flexion of a longitudinal support 10 on the porous surface until the amount of flexion allow the edges 20 of adjacent circumferential rings 25 to contact each other, at which point no additional bending (tension) can be applied to the longitudinal support 10. Consequently, there is a limit on the amount of stress that can be placed on the longitudinal support 10 of that thereby reducing the likelihood of twisting, deformation and/or failure of the material used to produce the porous surface of the stent delivery device 5.
[090] With reference to figures 38(a)-38(d), the dimensions for the elements O, P, Q and R appearing in these drawings indicate the simultaneous transition for all these elements from one end of the device to the other end:

[091] The number of transitions in elements O, P, Q and R is not particularly limited. For example, in figure 38, there is a transition between circumferentially adjacent longitudinal supports (R) and longitudinally adjacent circumferential rings P., however, the transition can be achieved using a smaller number of steps - for example, by having subsections with dimensions constants for O, P, Q and R. in this last mentioned modality the subsections can be of similar or different longitudinal length. It is also possible to use a combination of one or more subsections with a series of individual transitions.
[092] The delivery device modality shown in Fig. 38 preferably has a smaller diameter than that of the delivery catheter 140, 440. Preferably, the delivery device is in the range of approximately 0.3 to approximately 0.89 mm, more preferably from about 0.06 to about 0.09 mm, more preferably 0.6 mm.
[093] The stent delivery device 5 is particularly well suited for delivering the present stent particularly when it is desired to deliver that stent through the tortuous stent in a patient. Of course, it will be recognized that the stent delivery device 5 can be used to deliver other types of stents.
[094] Figures 38-43 illustrate enlarged views of the distal portions of the various distribution devices described above identified with reference numerals ending in "30". The following is a concordance of the above-described delivery devices and the above-described stent preferably provided by that delivery device:

[095] As can be seen in Figures 39-43, the porous tubular portion of each delivery device is very similar, however the distal section that is used to attach to the stent varies in each modality to accommodate the specific type of endovascular prosthesis. In the figures, the distal section that is used to secure the stent is heat-hardened (for example, when the delivery device is constructed of a memory alloy shaped like nitinol) to facilitate delivery of the stent - this is particularly advantageous when it is desired to deliver the stent to a bifurcated artery. The point is, a person of ordinary skill in the art having this descriptive report in hand will understand that the specific nature of the distal section that is used to attach to the stent is not specifically limited. In addition, a person with ordinary skill in the art will understand, having this descriptive report in hand, that it may be possible to mix and match certain illustrated modalities of the stent with certain illustrated modalities of the stent delivery device with or without minor modifications in a or both of these.
[096] In a highly preferred embodiment, the present stent delivery device is also provided with a covering layer on the porous surface thereof. The cover layer may be disposed on one or both of the inner and outer surfaces of the porous surface of the stent delivery device. It has been found that the provision of such a cover layer prevents or lessens friction between the stent delivery device and the interior of the delivery catheter conventionally used to deliver the stent. Preferably, the cover layer is made of a biocompatible polymer which can be a natural or synthetic polymer. Non-limiting examples of a suitable polymer may be selected from the group comprising polyurethanes, silicone materials, polyurethane/silicone combinations, rubber materials, woven and non-woven fabrics such as Dacron™, fluoropolymer compositions such as polytetrafluoroethylene (PTFE) materials ), expanded PTFE (ePTFE) materials such as and including Teflon™, Gore-Tex™, Softform™, Impra™ and the like. Preferably, the cover layer has a thickness in the range of approximately 0.00025 to approximately 0.000.25 m, more preferably the cover layer has a thickness of approximately 0.13 mm.
[097] The stent of the present invention may further comprise a coating material thereon. The coating material can be disposed continuously or discontinuously on the surface of the prosthesis. Furthermore, the coating may be disposed on the inner and/or outer surface(s) of the prosthesis. The coating material can be one or more of a biologically inert material (eg to reduce stent thrombogenicity), a medicinal composition that leaches into the wall of the body passageway after implantation (eg to provide anticoagulant action, deliver a body passage pharmaceutical and the like), swellable/removable material (eg a hydrogel material) and the like.
[098] In addition, the present stent may be provided with a biocompatible coating to minimize adverse interaction with the body's vessel walls and/or with fluid, typically blood, flowing through the vessel. Several such coatings are known in the art. The coating is preferably a polymeric material, which is generally provided by applying a solution or dispersion of preformed polymer in a solvent to the stent and removing the solvent. Non-polymeric coating material can alternatively be used. Suitable coating materials, for example polymers, can be polytetrafluoroethylene or silicone rubbers, or polyurethanes which are known to be biocompatible. Preferably, however, the polymer has zwitterionic pendant groups, generically ammonium phosphate ester groups, for example, phosphoryl choline groups or the like.
[099] Examples of suitable polymers are described in international publication numbers WO-A-93/16479 and WO-A-93/15775. The polymers described in these documents are hemocompatible as well as generally biocompatible and, in addition, are lubricants. When such coatings are used, it is preferred that the stent surfaces be fully coated to minimize unfavorable interactions, for example, with blood, which could lead to thrombosis. This good coating can be achieved by proper selection of coating conditions such as coating solution viscosity, coating technique and/or solvent removal step.
[0100] The manner in which the present stent is manufactured is not particularly limited. Preferably, the stent is produced by laser cutting techniques or chemical etching applied to a tubular starting material. Thus, the starting material could be a thin tube of a metal or alloy (non-limiting examples include stainless steel, titanium, tantalum, nitinol, Elgiloy, NP35N, cobalt-chromium alloy and mixtures thereof), which would then have sections therefrom cut (by laser cutting or chemical cauterization) to provide a prosthesis having a predetermined design. Alternatively, it is possible to cut the design (by laser cutting or chemical cauterization) of the protease from a flat starting material and then roll the cut product into a tube and heat harden in such a configuration or whose edges could be welded or otherwise way fixed together to form a tubular device.
[0101] In a particularly preferred embodiment, the present stent is made of a suitable material that will expand when a certain temperature is reached. In this embodiment, the material may be a metal alloy (eg, nitinol) capable of self-expanding at a temperature of at least approximately 25°C, preferably in the range of approximately 25°C to approximately 35°C. in that preferred embodiment, it may be desirable and even preferable to heat harden the stent to adopt an unfolded configuration that has been optimized for the specific anatomy intended - for example, this is preferred for the stent 400, 500, 600 described above.
[0102] Although the present invention has been described with reference to illustrative embodiments and examples, the description is not intended to be interpreted in a limiting sense. Accordingly, various modifications of the illustrative embodiments, as well as other embodiments of the invention, will be apparent to persons skilled in the art upon reference to such description. For example, the illustrated embodiments use all leaf portions to act as a so-called flow diverter - that is, after the device is implanted, the leaf portion diverts blood flow away from the inlet of the aneurysm opening. In cases where the aneurysm opening is relatively large, it is possible to modify the leaf portion to act as a retaining element - for example retaining one or more Guglielmi Detachable Coils in the aneurysm. In this modification, the spacing between adjacent rib portions would be increased to a sufficient degree to allow distribution of one or more Guglielmi Detachable Coils across the sheet portion after implantation of the stent. Guglielmi Detachable Coils would be less likely to “fall out” of the aneurysm when the leaf portion of the present stent is covering the aneurysm opening. In addition, although the illustrated modalities depict the attachment of the stent to the stent delivery device using loop/wire wire systems with or without male-female connection systems, other approaches may also be used - for example, electrolytic approaches , thermal-mechanical, other mechanical and similar approaches can be adopted. Furthermore, although the illustrated modalities are focused on the treatment of a cerebral aneurysm, it is considered that the present stent can be used to treat other diseases such as aortic disease (for example, see the discussion of aortic disease presented in the international publication number WO 02/39924 [Erbel et al.]). In such a modification, it may be appropriate to change several of the dimensions mentioned above. For example, it is therefore considered that the appended claims will cover any such modifications or arrangements.
[0103] All publications, patents and patent applications mentioned herein are incorporated by reference in their entirety to the same extent as if each individual publication, patent or patent application were specifically and individually indicated as being incorporated by reference in full.

权利要求:
Claims (15)
[0001]
1. Stent delivery device (5, 130, 230, 330, 430, 530, 630) comprising a tubular member having a distal portion and a proximal portion, the distal portion having a porous surface defined by a plurality of circumferential rings (25), adjacent pairs of circumferential rings (25) being interconnected by at least one longitudinal support (10), CHARACTERIZED by the fact that the porous surface comprises a circumferential width decreasing gradient of longitudinal support between connected longitudinal supports (10) to opposite sides of a single circumferential ring in one direction from the proximal to the distal portion.
[0002]
2. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 1, CHARACTERIZED by the fact that each circumferential ring (25) comprises alternating peaks and valleys.
[0003]
3. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 2, CHARACTERIZED by the fact that at least one longitudinal support (10) connects a first valley to a first circumferential ring to a second valley in a second circumferential ring adjacent to the first circumferential ring.
[0004]
4. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 3, CHARACTERIZED by the fact that the first circumferential ring and the second circumferential ring each comprise at least two pairs of alternating peaks and valleys.
[0005]
5. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to any one of claims 2 to 4, CHARACTERIZED by the fact that it comprises a longitudinal support (10) for each valley .
[0006]
6. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 4, CHARACTERIZED in that it comprises a longitudinal support (10) for each pair of peaks and valleys alternated on the first circumferential ring or the second circumferential ring.
[0007]
7. Stent delivery device (5, 130, 230, 330, 430, 530, 630), according to claim 3, CHARACTERIZED by the fact that (i) the first circumferential ring and the second circumferential ring comprise, each a pair of alternating peaks and valleys, and (ii) two longitudinal supports interconnect the first circumferential ring and the second circumferential ring.
[0008]
8. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to any one of claims 1 to 7, CHARACTERIZED by the fact that it additionally comprises a fixed stent connecting portion to the distal portion.
[0009]
9. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 8, CHARACTERIZED in that the stent connecting portion comprises at least a first elongated section comprising an intermediate section and a distal section for connection to the stent.
[0010]
10. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 9, CHARACTERIZED by the fact that the intermediate section and the distal section are inclined in relation to each other.
[0011]
11. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 9, characterized in that the stent connecting portion comprises a pair of elongated sections comprising a first elongated section and a second elongated section.
[0012]
12. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 11, CHARACTERIZED by the fact that the first elongated section comprises an arranged first stent fixation portion at a distal end of it.
[0013]
13. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 12, CHARACTERIZED in that the first stent fixation portion comprises a first half of a first male-female connection system for receiving a second half of the first male-female connection system disposed in a stent.
[0014]
14. Stent delivery device (5, 130, 230, 330, 430, 530, 630), according to claim 13, CHARACTERIZED by the fact that the first half of the first male-female connection system comprises a first female portion and the second half of the first male-female connection system comprises a first male portion.
[0015]
15. Stent delivery device (5, 130, 230, 330, 430, 530, 630) according to claim 13 or 14, CHARACTERIZED by the fact that the first half and second half of the first male connection female are configured to receive a first stent release element and wherein preferably the first stent release element comprises a first wire element.

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法律状态:
2018-12-11| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2019-10-22| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

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2020-09-29| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|

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2021-03-16| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2021-05-25| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/04/2012, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

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US201161457605P| true| 2011-04-29|2011-04-29|

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US201161457604P| true| 2011-04-29|2011-04-29|

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US61/457.604|2011-04-29|

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US61/457.605|2011-04-29|

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PCT/CA2012/000388|WO2012145826A1|2011-04-29|2012-04-27|Endovascular prosthesis and delivery device|

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